Bacteriophages (phages), the natural predators of bacteria, are emerging as innovative tools in diagnostic imaging and precision therapy. In the oral cavity, where microbial infections and oral cancers are significant clinical concerns, phage-based strategies offer a non-invasive, targeted approach for both detection and treatment. This short communication explores the convergence of bacteriophage technology and oral imaging for early microbial diagnosis and treatment, while also highlighting evolving applications in imaging and targeted therapy for oral cancer.